AOD-9604
A modified fragment (amino acids 177-191) of human growth hormone with a tyrosine substitution. Studies have investigated its lipolytic properties without the growth-promoting or diabetogenic effects associated with full-length hGH.
From ReVia
Mechanism of Action
AOD-9604 corresponds to the C-terminal fragment of human growth hormone (hGH 177-191) with an additional tyrosine residue at position 177. Research suggests it mimics the lipolytic action of hGH by stimulating beta-3 adrenergic receptors on adipocytes and enhancing fat oxidation, while lacking the IGF-1-stimulating and hyperglycemic effects of full-length growth hormone. In vitro and animal studies have shown it promotes lipolysis and inhibits lipogenesis in adipose tissue without affecting carbohydrate metabolism or promoting longitudinal bone growth.
Research Applications
- Studies have investigated its lipolytic activity in adipose tissue models
- Research has examined fat oxidation pathways without IGF-1 elevation
- Studies have explored its effects on body composition parameters in preclinical models
- Studies have assessed cartilage repair and regenerative potential
Key Published Studies
Heffernan MA, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta-3 AR knock-out mice. Endocrinology. 2001;142(12):5182-5189.
Key finding: Research investigated AOD-9604-mediated lipolytic signaling in obese mice, observing modulation of adipose tissue metabolism without IGF-1 stimulation or hyperglycemia, with effects shown to be mediated via beta-3 adrenergic receptors.
Stier H, et al. Safety and tolerability of the hexadecapeptide AOD9604 in humans. J Endocrinol Metab. 2013;3(1-2):7-15.
Key finding: Phase II evaluation examined the safety and tolerability profile of AOD-9604, observing a tolerability profile comparable to placebo.
Chemical Properties
- Type
- Peptide
- Molecular Formula
- C₇₈H₁₂₃N₂₁O₂₃S₂
- Molar Mass
- ~1815 g/mol
- CAS Number
- 221231-10-3
Research Use Only (RUO): This page summarizes published scientific research and is provided for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. The compound described carries a Research Use Only designation and is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in the diagnosis, treatment, cure, or prevention of any disease. Consult qualified professionals before making any health-related decisions.