GHRP-6
A synthetic hexapeptide growth hormone secretagogue with strong GH-releasing activity and notable appetite-stimulating properties. Studies have investigated its role in growth hormone release and gastric motility.
From ReVia
Mechanism of Action
GHRP-6 (Growth Hormone Releasing Peptide 6) is one of the earliest synthetic GH secretagogues discovered. It binds to the GHS-R1a receptor on pituitary somatotrophs and hypothalamic neurons, stimulating GH release and simultaneously suppressing somatostatin. Unlike GHRP-2, GHRP-6 produces a more pronounced increase in appetite through its ghrelin-mimetic activity, stimulating gastric acid secretion and gastric motility. It also produces more significant elevations in cortisol and prolactin compared to more selective GHRPs like ipamorelin. GHRP-6 has been studied for its cytoprotective effects on various tissues, including gastric mucosa.
Research Applications
- Studies have investigated GH release and IGF-1 elevation in various research models
- Research has examined its appetite-stimulating properties and effects on gastric motility
- Studies have explored cytoprotective effects on gastric and hepatic tissue
- Research has examined its effects on cardiac function and myocardial signaling pathways
Key Published Studies
Bowers CY. Growth hormone-releasing peptide (GHRP). Cell Mol Life Sci. 1998;54(12):1316-1329.
Key finding: Comprehensive characterization of GHRP-6 as a potent GH secretagogue with distinct pharmacological properties including appetite stimulation and cortisol/prolactin co-release.
Berlanga-Acosta J, et al. Synthetic growth hormone-releasing peptides (GHRPs): a historical appraisal of the evidence supporting their cytoprotective effects. Clin Med Insights Cardiol. 2017;11:1179546817694558.
Key finding: Reviewed evidence for GHRP-6 cytoprotective signaling across multiple tissue types, including cardioprotective and hepatoprotective mechanisms in ischemia-reperfusion research models.
Chemical Properties
- Type
- Peptide (hexapeptide)
Research Use Only (RUO): This page summarizes published scientific research and is provided for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. The compound described carries a Research Use Only designation and is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in the diagnosis, treatment, cure, or prevention of any disease. Consult qualified professionals before making any health-related decisions.