Tesamorelin
A stabilized GHRH analog with a trans-3-hexenoic acid modification. An extensively studied compound that has been investigated for its effects on GHRH receptor-mediated signaling and visceral adipose tissue metabolism.
From ReVia
Mechanism of Action
Tesamorelin is a synthetic analog of human GHRH(1-44) with a trans-3-hexenoic acid group attached to the tyrosine at position 1 via the amino terminus. This modification provides resistance to enzymatic degradation by DPP-IV, extending its biological activity. Like native GHRH, tesamorelin activates the GHRH receptor on pituitary somatotrophs to stimulate pulsatile GH release and subsequent hepatic IGF-1 production. Studies have investigated its effects on visceral adipose tissue metabolism, demonstrating modulation of trunk fat distribution, with observations of changes in trunk fat-to-limb fat ratio in research settings.
Research Applications
- Studies have investigated GHRH receptor-mediated effects on visceral adipose tissue metabolism
- Research has examined effects on hepatic lipid content and related biomarkers
- Studies have investigated cognitive signaling effects in aging research models
- Research has assessed effects on cardiovascular biomarkers including triglycerides and CRP
Key Published Studies
Falutz J, et al. Metabolic effects of a growth hormone-releasing factor in patients with HIV. N Engl J Med. 2007;357(23):2359-2370.
Key finding: Research investigated GHRH receptor-mediated effects on visceral adipose tissue metabolism over 26 weeks, observing modulation of adipose tissue distribution parameters.
Stanley TL, et al. Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation. JAMA. 2014;312(4):380-389.
Key finding: Research examined the relationship between GHRH receptor activation and hepatic lipid metabolism, investigating effects on both visceral adipose tissue and hepatic fat fraction biomarkers.
Chemical Properties
- Type
- Peptide (modified GHRH analog)
Research Use Only (RUO): This page summarizes published scientific research and is provided for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. The compound described carries a Research Use Only designation and is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in the diagnosis, treatment, cure, or prevention of any disease. Consult qualified professionals before making any health-related decisions.